The American College of Medical Genetics and Genomics (ACMG) is pleased to join the Choosing Wisely® campaign. Our board certified specialists include clinical geneticists as well as directors of clinical biochemical, cytogenetic, and molecular genetics laboratories. Tests performed by the laboratories are utilized by clinical geneticists as well as other medical specialists and primary care physicians. The number and complexity of genetic tests are increasing as genomic advances occur. Health care professionals in all disciplines with an admitted low level of comfort with their knowledge in this area, create the potential for misuse and incorrect or inappropriate ordering of genetic tests. Some large genetics laboratories have reported considerable incorrect ordering of tests or misuse that has a significant impact on quality of care, as well as health care costs. It also leads to unnecessary patient anxiety. In part, this has led to the establishment of alternative forms of oversight of genetic testing by payers and institutions. ACMG looks forward to working with the broader medical community to find ways to improve the use and ordering of genetic and genomic tests.