The American Academy of Clinical Toxicology (AACT) is proud to participate in the Choosing Wisely® campaign. Founded in 1968, the AACT is a multidisciplinary organization uniting scientists and clinicians in the advancement of research, education, prevention, and treatment of diseases caused by chemicals, drugs and toxins. Given the vast and growing array of occupational, environmental and pharmaceutical poisonings, the increased awareness of personal health and environmental exposures, and the availability of alternative therapies it is essential that patients have informed conversations with their providers regarding both the diagnosis of suspected poisoning and the most appropriate treatment options once that diagnosis has been confirmed. Choosing Wisely is an extension of positions held by the AACT and publications in our highly cited and peer reviewed journal Clinical Toxicology that focus on optimal testing and treatment strategies for suspected poisoning. We enthusiastically support the ABIM Foundation’s Choosing Wisely initiative and are honored to be able to participate.